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| Electrospun nanofibers for Tissue Engineering |
| Xiumei Mo, Dawei Li, Hany A. EI-Hamshary, Salem S. Al-Deyab |
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Abstract Electrospun nanofibers have increasingly attracted attention to be used as new generation tissue engineering scaffolds since they have the nanofibrous structure, which can biomimic the native Extracellular Matrix (ECM). This paper gives the review of our 10 years research on electrospun nanofibers for tissue engineering. Natural polymers like collagen and chitosan have been electrospun into complex nanofibers to biomimic the native ECM both in structure and components. Collagen-chitosan or silk fibroin (SF) was also blended with synthetic poly (L-lactide-co-ε-caprolactone) (P(LLA-CL)) and electrospun into collgen-chitosan-P (LLA-CL) nanofibers or SF-P(LLA-CL) nanofibers to achieve both good mechanical properties and biocompatibility. Coaxial electrospinning was used to encapsulate the biomolecules into nanofibers to display antithrombotic properties. The nanofiber scaffolds have been used for skin, nerve and blood vessel tissue engineering in vivo.
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| Cite this article: |
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Xiumei Mo,Dawei Li,Hany A. EI-Hamshary, et al. Electrospun nanofibers for Tissue Engineering[J]. Journal of Fiber Bioengineering and Informatics, 2013, 6(3): 225-235.
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[1] Piez KA. Molecular and aggregate structures of the collagens. In: Reddi AH, editor. Extracellular Matrix Biochemistry. New York: Elsevier. 1984; 1-35.
[2] Kim BS and Mooney DJ. Development of biocompatible synthetic extracellular matrices for tissue engineering. TIBTECH. 1998; 16: 224-230.
[3] Patch K and Body S. E. Handles nanofiber better. Technology Research News. 2003; 17: 24.
[4] Pattison MA, Wurster S, Webster TJ, Haberstroh KM. Three-dimensional nano-structured PLGA scaffolds for bladder tissue replacement applications. Biomaterials. 2005; 26(15): 2491-2500.
[5] Elias KE, Price RL, Webster TJ. Enhanced functions of osteoblasts on nanometer diameter carbon fibers. Biomaterials, 2002; 23: 3279-3287.
[6] Stevens MM, George JH. Exploring and engineering the cell surface interface. Science. 2005; 310: 1135-1138.
[7] Yoshimoto H, Shin YM, Terai H, Vacanti JP. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials. 2003; 24: 2077-2082.
[8] Min BM. Chitin and chitosan nanofibers: electrospinning of chitin and deacetylation of chitin nanofibers. Polymer. 2004; 45: 7137-7142.
[9] Xu CY, Inai R, Kotaki M, Ramakrishina S. Aligned biodegradable nanofibrous structure: a po-tential scaffold for blood vessel engineering. Biomaterials. 2004; 25: 877-886.
[10] Su Y, Li XQ Liu YN, Su QQ, Lim M, Qiang W, Mo XM. Encapsulation and controlled release of heparin from electrospun Poly(L-Lactide-co--Caprolactone) nanofibers, Journal of Biomaterials Science. 2011; 22: 165-177.
[11] Wang CY, Liu JJ, Fan CY, Mo XM, Ruan HJ, Li FF. The Effect of aligned core-shell nanofibres delivering NGF on the promotion of sciatic nerve regeneration. Journal of Biomaterials Science, Polymer Edition. 2012; 23(1-4): 167-184.
[12] Chen ZG, Mo XM, Qing FL. Electrospinning of collagen-chitosan complex, Materials Letter, 2007; 61: 3490-3494.
[13] Chen ZG, Wei B, Mo XM, Lim CT, Ramakrishna S, Cui FZ. Mechanical properties of electrospun collagen-chitosan complex single fibers and membrane. Materials Science and Engineering C. 2009; 29: 2428-2435.
[14] Chen ZG, Wei B, Mo XM, Cui FZ. Diameter control of electrospun chitosan-collagen fibers. Polyp. Sci Part B: Polym. Phys. 2009; 47: 1949-1955.
[15] Zhang KH, Fan LP, Yan ZY, Yu QZ, Mo XM. Electrospun biomimic nanofibrous scaffolds of silk fibroin/hyaluronic acid for tissue engineering. Journal of Biomaterilas Science-Polymer Edition, 2012; 23(9): 1185-1198.
[16] Zhang KH, Yu QZ, Mo XM. Fabrication and intermolecular interactions of silk fibroin/hydroxybutyl chitosan blended nanofibers. International Journal of Molecular Sciences. 2011; 12: 2187-99.
[17] Zhang KH, Qian YF, Wang HS, Fan LP, Huang C, Mo XM. Electrospun silk fibroin-hydroxybutyl chitosan nanofibrous scaffolds to biomimic extracellular matrix. Journal of Biomaterials Science-Polymer Edition. 2011; 22: 1069-82.
[18] Chen ZG, Mo XM, He CL and Wang HS. Intermolecular interactions in electrospun collagen-chitosan complex nanofibers. Carbohydrate Polymers, 2008; 72(3): 410-418.
[19] Chen ZG, Wang PW, Wei B, Mo XM, Cui FZ. Electrospun collagen-chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell. Acta Biomaterialia. 2010; 6: 372-382.
[20] Yin AL, Zhang KH, McClure M J, Huang C, Fang J, Wu JL, Bowlin G L, Mo XM, Al-Deyab SS, El-Newehy M. Electrospinning collagen/chitosan/poly(L-lactic acid-co-e-caprolactone) to form a vascular graft: mechanical and biological characterization. Journal of Biomedical Materials Re-search Part A. 2013; 101A: 1292-1301.
[21] Konig G, McAllister TN, Dusserre N, Garrido SA, Iyican C, Marini A, Fiorillo A, Avila H, Wys-trychowski W, Zagalski K, Maruszewski M, Linthurst Jones A, Cierpka L, de la Fuente LM, L'Heureux N. Mechanical properties of completely autologous human tissue engineered blood ves-sels compared to human saphenous vein and mammary artery. Biomaterials 2009; 30: 1542-155.
[22] L'Heureux N, Dusserre N, Konig G, Victor B, Keire P, Wight TN, Chronos NAF, Kyles AE, Gregory CR, Hoyt G, Robbins RC, McAllister TN. Human tissue engineered blood vessel for adult arterial revascularization. Nat Med 2006; 12: 361-365.
[23] Zhang KH, Wang HS, Huang C, Su Y, Mo XM, Ikada Y. Fabrication of silk fibroin blended P(LLA-CL) nanofibrous scaffolds for tissue engineering. J Biomed Mater Res A. 2010; 93(3): 984-993.
[24] Zhang KH, Yin AL, Huang C, Wang CY, Mo XM, Al-Deyab SS., El-Newehy M. Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro. Polymer Degradation and Stability. 2011; 96: 2266-75.
[25] Li XQ, Su Y, Chen R, He CL, Wang HS, Mo XM. Fabrication and properties of core-shell structure P(LLA-CL) nanofibers by coaxial Electrospinning. J Appl Polym Sci. 2009; 111: 1564-1570.
[26] Su Y, Li XQ, Wang HS, He CL, Mo XM. Fabrication and characterizations of biodegradable nanofibrous mats by mix and coaxial electrospinning of Poly(L-lactid-co--caprolactone). Journal of Materials Science: Materials in Medicine. 2009 C; 20: 2285-2294.
[27] Li XQ, Su Y, Zhou X, Mo XM. Distribution of sorbitan monooleate in poly(l-lactide-co-caprolac-tone) nanofibers from emulsion electrospinning. Colloids and Surfaces B: Biointerfaces. 2009; 69: 221-224.
[28] Su Y, Li XQ, Liu SP, Mo XM, Ramakrishna S. Controlled release of dual drugs from emulsion electrospun nanofibrous mats. Colloids and interfaces B: Biointerfaces. 2009; 73 (2): 376-381.
[29] Chen R, Huang C, Ke QF, He CL, Wang HS, Mo XM. Preparation and characterization of coax-ial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications. Colloids and Surfaces B: Biointerfaces. 2010; 79: 315-325.
[30] Huang HH, He CL, Wang HS, Mo XM. Preparation of core-shell biodegradable microfibers for long-term drug delivery. J Biomed Mater Res A. 2009; 90A (4): 1243-1251.
[31] Su Y, Li XQ, Tan LJ, Huang C, Mo XM. Electrospun Poly(L-lactide-co-ε-caprolactone) nanofibers for encapsulating and sustained releasing proteins. Polymer. 2009; 17(50): 4212-4219.
[33] Chen F, Huang P, Mo XM. Electrospinning of heparin encapsulated P(LLA-CL) core/shell nanofibers. Nano Biomedicine and Engineering, 2010; 2: 84-90.
[34] Su Y, Su QQ, Liu W, Lim M, Venugopal JR, Mo XM. Ramakrishna S, Salem S. Al-Deyab, Mohamed El-Newehy. Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering, Acta Biomaterialia. 2012; 8: 763-771.
[35] Yu PJ, Wang LP, Guo S, Chen W, Mo XM. Collegen-chitosan complex nanofibers for skin tissue regeneration. Journal of Clinical Rehabilitative Tissue Engineering Research. 2011; 15(51): 9561-9564.
[36] Zhang KH, Wu JL, Huang C, Mo XM. Fabrication of silk fibroin/P(LLA-CL) aligned nanofibrous scaffolds for nerve tissue engineering. Macromolecular Materials and Engineering. 2013; 298(5): 565-574.
[37] Wang CY, Zhang KH, Fan CY, Mo XM, Ruan HJ, Li FF. Aligned natural-synthetic polyblend nanofibers for peripheral nerve regeneration. Acta Biomaterialia. 2011; 7: 634-643.
[38] Huang C, Wang S, Qiu LJ, Ke QF, Zhai W, Mo XM. Heparin loading and pre-endothelialization in enhancing the patency rate of electrospun small-diameter vascular grafts in a canine model, ACS Appl. Mater. Interfaces 2013; 5: 2220-2226.
[39] Wang S, Mo XM, Jiang BJ, Gao CJ, Wang HS, Zhuang YG, Qiu LJ. Fabrication of small-diameter vascular scaffolds by heparin-bonded P(LLA-CL) composite nanofibers to improve graft patency. International Journal of Nanomedicine. 2013; 8: 2131-2139.
[40] Wu JL, Huang C, Liu W, Yin AL, Chen WM, Liu S, Fan CY, Mo XM, Bowlin GL. Electrospun nanoyarn scaffold and its application in tissue engineering. Materials Letter. 2012; 89: 146-149.
[41] Li J, Liu W, Yin AL, Wu JL, Al-Deyab SS, El-Newehy M, Mo |
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2013, Vol. 6 
