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| Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials |
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Shanghai Biomaterials Research & Testing Center, Shanghai 200023, China
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University
Shanghai 201620, China |
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Abstract The objective of this study was to develop an original anti-bacterial material for skin wound healing.
Collagen-chitosan nanofibrous membranes were fabricated by electrospinning. The morphology, tensile
strength and contact angle of the membranes were measured. In addition, cell adhesion and proliferation
on the membranes were evaluated. The antimicrobial property against Staphylococcus aureus of the
membranes was also determined. The results indicated that the diameter of electrospun collagen-chitosan
nanofibrous membranes was 221 § 105 nm, the tensile strength was 1.53 § 0.12 Mpa and the contact angle
was 42.44 § 4.03±. Besides, the collagen-chitosan nanofibrous membranes promoted cell attachment and
proliferation and also inhibited the growth of Staphylococcus aureus. In conclusion, these data suggest
that electrospun collagen-chitosan nanofibrous membranes have potential to serve as skin wound healing
materials, which might be ascribed to its favorable mechanical strength, excellent cell affinity, as well as
good antimicrobial properties against Staphylococcus aureus.
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| Fund:
This work was supported by grants from Shanghai Sci-Tech Committee Foundation (No.
13DZ2291100), and also supported by Doctoral Innovation Fund from Shanghai Jiaotong Univer-
sity School of Medicine (No. BXJ201335).
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| Cite this article: |
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Tian Zhou,Xiumei Mo,Jiao Sun. Development and Properties of Electrospun Collagen-chitosan Nanofibrous Membranes as Skin Wound Healing Materials[J]. Journal of Fiber Bioengineering and Informatics, 2014, 7(3): 319-325.
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2014, Vol. 7 
